Significance of fetal hemoglobin-containing erythroblasts (F blasts) and the F blast/F cell ratio in myelodysplastic syndromes
نویسندگان
چکیده
منابع مشابه
Immunophenotypic features of granulocytes, monocytes, and blasts in myelodysplastic syndromes.
BACKGROUND Despite the diagnostic utility of immunophenotyping for myelodysplastic syndromes (MDS), it has not been widely performed, and reports on this are absent in Korea. We aimed to evaluate the immunophenotypic features of non-blastic granulocytes, monocytes, and blasts in patients with MDS and non-clonal disorders using routine flow cytometry (FCM). Moreover, we evaluated the phenotypic ...
متن کاملVariation of Fetal Hemoglobin and F-Cell Number With the LCR-HS2 Polymorphism in Nonanemic Individuals
To the Editor: remains const t and seems to be under genetic control.' Available data suggest that at least two types of genetic determinants might In normal adults. synthesis of fetal hemoglobin (HbF) persists at be involved in the level of HbF expression: one linked to the pa very low level ( < I % ) and is restricted to a subpopulation of globin gene cluste?.' and the other(s) unlinke...
متن کاملClinical significance of phenotypic features of blasts in patients with myelodysplastic syndromes
Knowledge of the blast phenotype in myelodysplastic syndromes (MDS) would be valuable, as in other malignancies, but remains sparse. This is mainly because MDS blasts are a minor population in clinical samples, making analysis difficult. Thus, for this blast phenotype study, we prepared blast-rich specimens (using a new density-centrifugation reagent for harvesting blasts) from blood and marrow...
متن کاملVariation of fetal hemoglobin and F-cell number with the LCR-HS2 polymorphism in nonanemic individuals.
To the Editor: remains const t and seems to be under genetic control.' Available data suggest that at least two types of genetic determinants might In normal adults. synthesis of fetal hemoglobin (HbF) persists at be involved in the level of HbF expression: one linked to the pa very low level ( < I % ) and is restricted to a subpopulation of globin gene cluste?.' and the other(s) unlinke...
متن کاملHemoglobin synthesis in siderocytes of flexed-tailed mutant (f/f) fetal mice.
Mice carrying two mutant genes at the f locus on chromosome 1 3 have severe anemia during fetal development, characterized by hypochromic and microcytic red blood cells laden with many iron granules. Ultrastructural studies reveal that the cxcessive nonheme iron accumulated in mutant ( f/f ) fetal erythrocytes is present within mitochondria, similar to those seen in human sideroblastic anemia. ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2002
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2402536